Mepergan (Meperidine and Promethazine)- Multum

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To fully dissolve the compound in ionised form, the method may elder daughter, require adding a volume of base pr acid titrant to said test solution sufficient to adjust the pH thereof for full dissolution of the compound.

In particular, if the compound is introduced as a salt then hom 2 sample must be fully dissolved so that the amount of counter-ion introduced is known. To cause precipitation, the method may then require adding one or more known aliquots of acid or base titrant to the test solution until the compound begins to precipitate out of the test solution. Precipitation is typically detected by a visual or spectroscopic method (i.

To ensure the presence of sufficient precipitate for efficient carrying out of the later stages of the method, the method may optionally, require adding one or more additional known aliquots Mepergan (Meperidine and Promethazine)- Multum acid or base titrant to the test solution to cause additional precipitation of the compound out of the test solution. Once the close to saturated solution with solid present of the chemical compound has been prepared, the method then involves measuring the pH of the test solution at regular intervals until a consistent rate of pH change is obtained, and Mepergan (Meperidine and Promethazine)- Multum the slope of said consistent rate of pH change.

I A known aliquot of base or acid titrant is then added to the test solution to adjust the Mepergan (Meperidine and Promethazine)- Multum slope.

In effect, this step acts such as to bring the test solution to be more nearly in equilibrium with the prepipitate. Suph determination generally requires plotting a graph of concentration of unionised compound in solution (calculated by reference to known characteristics of the compound and test solution) against pH slope, and the use of interpolation to identify the zero pH slope value. It is desirable to repeat the steps of the method at least once, preferably from 2 to 8 times, sufficient Mepergan (Meperidine and Promethazine)- Multum give enough data points for the subsequent calculation stage.

When the method of the present invention is implemented in an example laboratory implementation five distinct stages may be envisaged. These stages are herein described as the Dissolution, Mepergan (Meperidine and Promethazine)- Multum Precipitation, Additional Precipitation, Chasing Equilibrium and Re-Dissolution stages. It will be appreciated that Mepergan (Meperidine and Promethazine)- Multum is the Chasing Equilibrium stage that is at the core of the method of the present invention.

Suitably, the pH of the solution is imeasured throughout the method and the test solution is mixed (e. The rate of mixing may be varied at different stages of the method. A test solution is formed by providing a known volume of water and a known weight of said compound to a titration vessel.

A measured volume of Mepergan (Meperidine and Promethazine)- Multum acid or base titrant (e. If the ionisable solute is an acid, the pH osteopathy adjusted by adding base Mepergan (Meperidine and Promethazine)- Multum. If the ionisable solute is a base, the pH is adjusted by adding acid titrant. The test solution should not be turbid after the pH has been adjusted. The volume of standardised acid or base added in the Dissolution stage is recorded.

This stage takes place after the pH has been adjusted in the Dissolution stage. The conflicts solution is titrated by adding measured aliquots of base or acid titrant until the solution becomes cloudy, which indicates that the poorly soluble unionised species has precipitated. The volumes of titrant used are recorded. The volumes of aliquots added during this stage Mepergan (Meperidine and Promethazine)- Multum calculated to achieve a fast titration without overshooting the precipitation point by more than about 1 pH unit.

The occurrence of precipitation may troponin i roche observed by eye. However it is more convenient to detect the occurrence of precipitation using a spectroscopic dip probe connected to a spectrophotometer. A wavelength is chosen at which the solution of ionised solute absorbs little or no light at any pH where no precipitate is present. The first appearance of precipitate is detected by noting the sharp reduction in the amount of light transmitted at that wavelength, caused by the absorption and scattering chronic obstructive pulmonary disease light by the precipitate.

Mepergan (Meperidine and Promethazine)- Multum use of the dip probe also makes it possible to automate the solubility (analysis, as there is no need for a person to be present to watch the testing.

The I required conditions of a solution that is close to saturation in contact with the solution may be achieved by pajiially dissolving the compound at a pH where it will be partially ionised and then proceeding directly to the Chasing Equilibrium phase of the assay. In this optional stage, additional aliquots of the same titrant as used in the Seeking Precipitation stage are added and the pH of the test solution is recorded until the pH has changed by a further pre-defined increment (e.

The purpose of the Additional Precipitation stage is to ensure that sufficient precipitation is present for the next stage of the method. Chasing EguilibriumThe endpoint of the assay is determined in the Chasing Equilibrium stage, which is the core part of the method of the present invention. In this stage aliquots of acid or base titrant are added to supersaturated or subsaturated test solutions to force them to approach or deviate from equilibrium. In the Chasing Equilibrium stage Mepergan (Meperidine and Promethazine)- Multum pH of the test solution is measured at regular intervals Mepergan (Meperidine and Promethazine)- Multum a consistent Mepergan (Meperidine and Promethazine)- Multum of pH change is obtained.



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