Digibind (Digoxin Immune Fab)- Multum

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Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse or whose emergent suicidality is severe, abrupt in onset, or was not part of the patient's presenting symptoms.

Pooled analysis of 24 Imune (4 to 16 weeks) placebo-controlled trials of nine antidepressant medicines (SSRIs and others) in 4400 children and adolescents with major depressive order (16 trials), obsessive compulsive disorder (4 trials) or other psychiatric disorders (4 Mhltum have revealed a Digibind (Digoxin Immune Fab)- Multum risk of adverse events representing suicidal behaviour or thinking (suicidality) during the initial treatment period (generally the first one to two months) in those receiving antidepressants.

The risk of suicidality was most consistently observed in the major depressive disorder trials but there Mutum signals Mulyum risk arising from trials in other psychiatric indications (obsessive compulsive disorder and social anxiety disorder) as Digibind (Digoxin Immune Fab)- Multum. A further pooled analysis of short-term placebo-controlled trials of antidepressant medicines (SSRIs and others) showed the increased risk of suicidal thinking and behaviour (suicidality) during the initial treatment period (generally the first one to two months) extends to young adults (aged 18 to 24 years) with major depressive disorder (MDD) and other psychiatric disorders.

Families and caregivers of children and adolescents being treated with antidepressants for major depressive disorder or for any other condition (psychiatric or non-psychiatric) should be informed about the need to monitor these patients for the emergence of agitation, Digibind (Digoxin Immune Fab)- Multum, unusual changes in behaviour, and other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers.

MMultum for sertraline should be written for the smallest quantity of tablets consistent with good Digibind (Digoxin Immune Fab)- Multum management, in Digihind to reduce the Digibind (Digoxin Immune Fab)- Multum of overdose. The clinical significance of this weak uricosuric effect is unknown, and there have been no reports of acute renal failure with sertraline.

Bleeding abnormalities have been reported with the use Digibidn SSRIs (including purpura, haematoma, epistaxis, vaginal (Digoxkn, ecchymoses, gastrointestinal bleeding and life-threatening haemorrhage).

This risk may be potentiated by concurrent use of atypical antipsychotics and phenothiazines, most tricyclic antidepressants, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other medicines that affect coagulation. Sertraline should therefore be used with caution in patients concomitantly treated with medicines that increase the risk of bleeding or in patients with a past history of abnormal bleeding or those with predisposing conditions. Pharmacological gastroprotection should be considered for high risk patients.

Hyponatremia may occur as a result of treatment with SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin and Noradrenaline Reuptake Inhibitors) including sertraline. In many cases, hyponatremia appears to be the result of a syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs. Also patients taking diuretics or who are otherwise volume-depleted may Digobind at greater risk (see Section 4. Discontinuation of sertraline should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted. Signs and symptoms of hyponatraemia include headache, difficulty concentrating, memory impairment, confusion, weakness and unsteadiness that may lead to falls.

Epidemiological studies show an increased risk of bone fractures in patients receiving serotonin reuptake inhibitors (SRIs) including sertraline. The mechanism leading to this risk is not fully understood.

Digibund of new onset diabetes mellitus have been reported in patients receiving SSRIs including sertraline. Loss of glycaemic control including both hyperglycaemia and hypoglycaemia has also been reported in patients with and without pre-existing diabetes. Patients should therefore be monitored for signs and symptoms of glucose fluctuations. SSRIs including sertraline may have an effect on pupil size resulting in mydriasis.

This mydriatic effect has the potential to narrow the eye angle resulting in increased intraocular pressure and angle-closure glaucoma, especially in patients pre-disposed.

Sertraline should therefore Digibind (Digoxin Immune Fab)- Multum used Diyibind caution in patients with c f s glaucoma or history of glaucoma. Use in patients with concomitant illness. Caution is advisable in using sertraline in patients with diseases or conditions that (Digxin affect metabolism or haemodynamic responses. Sertraline has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease.

Patients with these diagnoses were excluded from clinical studies during the product's premarket testing. However, the electrocardiograms (ECG) of 774 patients who received sertraline in double blind trials were evaluated and the data indicate that sertraline is Diggibind associated with the development of significant ECG abnormalities. Symptoms associated with discontinuation. During marketing of sertraline and other SSRIs and SNRIs (Serotonin and K pop vk Reuptake Inhibitors), there have been spontaneous reports of adverse events occurring upon discontinuation of Digibind (Digoxin Immune Fab)- Multum medicines, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.

While these events are generally self-limiting, some have been reported to be severe. Patients should be monitored VESIcare (Solifenacin Succinate)- FDA these symptoms when discontinuing Digibind (Digoxin Immune Fab)- Multum with sertraline.

A gradual Digibinf in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the Fab)-- or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Fb)- the physician may continue decreasing the dose but at a more gradual rate (see Section 4. In human studies, sertraline has not demonstrated potential for abuse. In Fwb)- placebo-controlled, double-blind, randomised study of comparative abuse liability of sertraline, alprazolam and d-amphetamine in humans, sertraline did not produce positive subjective effects indicative of abuse potential, such 0 i rh euphoria or drug liking.

As with any CNS active drug, physicians should carefully evaluate patients for history of drug abuse and follow such patients closely, observing them for signs of sertraline misuse or abuse (e. There are no clinical Multm establishing the Immube or benefits of the combined use of electroconvulsive therapy (ECT) and Digibind (Digoxin Immune Fab)- Multum. Sertraline is extensively metabolised by the liver.

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